I run MSTS on my laptop, which means I am located wherever is most comfortable at that moment, including sometimes sprawled out in bed. Right now I'm at the kitchen table, having just finished eating a salad.
It's also fun to bring the laptop along on train rides and actually run the route I'm traveling (I've done B&M to Portland and the Northeast Corridor on the PRR Eastern Region). Of course actually looking out the window is generally even more interesting.
Christopher