I'm happy I was able to contribute to the community but this isn't just a list. This is the settings file I use.
You can drop it in your TSRE folder and use it. Change yours by adding a 1 to the end, ie. settings.txt1, if you want to save it.
Some of the changes from default are,
TSRE opens "full" screen. This can be problematic as it can't be minimized, only saved and closed using the route button. I have two monitors so it's not a big deal. You can change it by commenting out fullscreen.
I have it set to load all W files. It will show all route errors in the Errors and Messages window under the tools dropdown. I have used the FixAll option without any problems but it's commented out, just in case.
Mouse speed has been slowed down to more of a human speed, like drinking decaf.
Camera speed is about 20 mph, +shift is about 100 and +ctrl kicks in the afterburner so you can get somewhere in a hurry.
I changed the shape viewer and CE windows to more of a sky blue background.
You'll have to add your own mapbox key.
Goku is still working on some of the features so I imagine a lot of the settings have no current function.