The other thing to consider is locals. I don't think this applies to your interests but perhaps others may get something out of it. Actually I will point something out which I call escape valves that may work for you.
There are 2 ways of running locals that save you time to do other things.
1) If you like switching you can AI the train to a certain point keeping an eye on the time and it's progress. Once it gets close give it a signal or switch into an intermediate yard or siding for switching. From there you can take over the train and perform all it's switching industries while continuing to do other switching if that is what you like or even run another mainline train finish it etc.
2) If you are not as interested in switching all the time but like to run a hump or key mainline operations you can do something what I call escape valves. These are industries that you build in the yard that turns over a train and all possible car types (usually requires 2 industires per track just like the fake industries I like to build that draws realistic or selected traffic to avoid cars you don't have or want in you operation). The key to this track is it simulates the switching because it takes loads and turns them into empties, empties into loads and retags them for various other locations that can be sorted once again in the hump.
The reason why I perfer this is I like to manage a yard, have limited switching (in other words I don't want to switch these big regions like crazy all day and night) and I do enjoy running mainline trains that are meaningful.
I think you and I are more of the option 2 type though I'm huge on operations. What I find operations do that when your trains are part of an overall system is it gives much more purpose. Which in return doesn't get you bored as quickly. For example for me just running trains a to b over time and seeing the same type of random AI trains gets boring. But having a job to do with that train as part of a system keeps my interest.
I'm sorry this is getting long as I'm hoping this sparks a flame for you or others. The reason why I'm looking forward to Railroader and perhaps smaller regions in Run8 (something that a solo person or small MP group of people you trust) is that running these class 1's with humps (as much as I do love the humps) usually means lots of trains and industries to deal with on a regular basis. This is also likely why I backed off of Run8 for a while and got interested in Medieval Dynasty.
Again sorry for the long post. Nothing wrong with Run8 as there are ways to make it happen with selected smaller regions you define as well. Sparks, CA and area may very well be a better territory but I'm not a fan of double track so I passed this one.
Thanks
Sean